Copper and Youth: GHK-Cu, The Regenerative Peptide
GHK-Cu is a tripeptide that naturally binds to copper in human plasma.
Blood levels of GHK-Cu drop significantly between ages 20 and 60.
It modulates over 4,000 genes, promoting a younger state of expression.
Stimulates collagen and elastin synthesis, improving skin firmness and elasticity.
Accelerates wound healing and the formation of new blood vessels.
Provides antioxidant and anti-inflammatory benefits, reducing oxidative stress.
The peptide was originally isolated in 1973 by Dr. Loren Pickart.
Professional Source:
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015). GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International, 2015, 648108.
BPC 157: The Body Protection Compound
BPC 157 is a short peptide sequence originally isolated from human gastric juice.
It is known for its remarkable ability to accelerate healing in many tissues.
Promotes tendon and ligament healing by increasing fibroblast growth.
It can protect organs and prevent ulcers in the gastrointestinal tract.
Stabilizes the gut-brain axis and has shown antidepressant-like effects.
Supports nitric oxide production, improving blood flow and angiogenesis.
Has an excellent safety profile in all tested studies, including humans.
Professional Source:
Sikiric, P., Seiwerth, S., Rucman, K., Kolenc, D., Rokotov, D. S., Oršolić, N.,… & Skok, D. S. (2020). Novel therapeutic aspects of the gastric pentadecapeptide BPC 157 and its derivatives. Current Pharmaceutical Design, 26(21), 2532-2541.
DSIP: Delta Sleep-Inducing Peptide
DSIP is a neuropeptide consisting of only nine amino acid residues.
Its primary role is associated with inducing slow-wave sleep (delta waves).
Thought to normalize sleeping patterns and improve sleep quality.
May help reduce stress and improve the body’s adaptation to stressors.
DSIP has shown potential in reducing pain and managing withdrawal symptoms.
It is believed to have antioxidant and anticarcinogenic properties.
The peptide was first isolated from rabbits in the mid-1970s.
Professional Source:
Kafi, S., Ghorbani, A., & Kafi, M. (2020). The role of delta sleep-inducing peptide (DSIP) in the regulation of sleep and wakefulness. Physiology and Behavior, 227, 113166.
KPV: The Anti-Inflammatory Fragment
KPV: The Anti-Inflammatory FragmentKPV is a tripeptide fragment of \alpha-Melanocyte Stimulating Hormone (\alpha-MSH).
It is recognized for its potent anti-inflammatory properties in various models.
Works primarily by inhibiting the NF-\kappaB pathway activation.
Shows promise in treating inflammatory bowel diseases and skin conditions.
Displays antimicrobial activity against certain types of bacteria and fungi.
Can promote wound healing by controlling the inflammation at the site.
The peptide’s full name is Lysine-Proline-Valine, based on its amino acids.
Professional Source:
Ma, C., Witte, D., & Li, W. Z. (2020). \alpha-MSH-derived tripeptide KPV-mediated inhibition of LPS-induced inflammatory responses via regulating the NF-\kappaB and MAPKs signaling pathways in RAW264.7 cells. Molecular Immunology, 125, 223-233.
Cortagen: The Gene-Regulating Peptide
Cortagen: The Gene-Regulating PeptideCortagen is a synthetic peptide known to modulate gene expression in the body.
It is a derivative of epithalamin, a natural peptide from the pineal gland.
Primarily influences the function and activity of connective tissue cells.
Has demonstrated potential in accelerating the healing of joint and cartilage damage.
Possesses anti-inflammatory properties, reducing swelling and tissue damage.
May help to regulate cell cycles, promoting tissue repair and regeneration.
Studied for its role in aging and its potential for anti-aging applications.
Professional Source:
Khavinson, V. K., Popovich, I. G., & Zavarzina, O. V. (2019). Peptide regulation of gene expression in connective tissue. BioMed Research International, 2019, 3940176.
TB-500: The Thymosin Beta-4 Derivative
TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4.
It is highly effective at promoting tissue repair and regeneration across the body.
Accelerates wound healing in skin, muscle, ligaments, tendons, and eyes.
Encourages the formation of new blood vessels (angiogenesis).
Reduces inflammation and chronic pain in injured or damaged tissues.
Has demonstrated protective effects on the heart muscle following injury.
The mechanism involves migration of actin and proliferation of stem cells.
Professional Source:
Malinda, K. M., Sidhu, K., Mani, H., Gunasekara, D., & Hider, B. (2014). Thymosin \beta 4 in tissue repair: therapeutic potential for diabetic wounds. Annals of the New York Academy of Sciences, 1332(1), 105-115.
